Johnic: I haven’t done specifically what you asked because I was already running 10.9 (Mavericks) on my aging Mac Pro when I bought a Zortrax M200. However, I did successfully run Z-Suite versions 1.3, 1.4 and 1.5 on 10.9 (Mavericks). When I upgraded to OS 10.10 (Yosemite) then 10.11 (El Capitan), Z-Suite V1.5 continued to run the same as it had - well but with excruciatingly slow slicing on even moderately complex models - 15 to 30 minutes in some cases.
Two important things:
1. You said “the latest Mono.” DO NOT DO THAT. You must install MonoFramework-MDK-188.8.131.52 and ONLY that version. Please don’t ask me how I know this but Z-Suite will not run on later versions of Mono (the latest release is 184.108.40.206).
2. Once installed, the Z-Suite versions I tried up thru V1.5 booted v-e-r-y slowly the first time but if I waited long enough they did start. The good news is, after that they boot in a few seconds like any other program. Unfortunately, so far V1.6 boots slowly every time I start it. On my 2008 8-core Mac Pro that’s 1-3/4 minutes.
Since it’s easy to install Z-Suite and easy to do a clean uninstall using any app cleaner, there’s little risk so give it a try.
BTW, you should find upgrades from your current 10.7 (Lion) to 10.8 (Mountain Lion) and 10.9 (Mavericks) pretty painless. The big jump in system requirements and program compatibility came with 10.10 (Yosemite). Despite my Mac Pro’s age it seems to run as well or better on 10.10 (Yosemite) and 10.11 (El Capitan). That said, “upgrading” my 2009 MacBook Pro to 10.10 (Yosemite) brought it to an absolute crawl. It took a few days but I finally restored 10.9 (Mavericks) and there it shall stay.